ABSTRACT
Objective:To probe the application and the effect of integration medical health education mode in the care-givers of children with capillary bronchitis. Method:Total 120 cases of capillary bronchitis caregivers were divided into control group (56 cases) and observation group (64 cases) and control group with traditional mode of health education, observing group adopts the integration medical health education mode;Compared two groups of children with hospitaliza-tion days, take care of health education knowledge of cooperation degree, satisfaction and health care work. Results:After implementation the integration medical health education mode, children hospitalization days declined. Caregivers' health education knowledge and satisfaction were obviously improved. The medical work cooperation degree is higher than the control group. Conclusions:The implementation of the new mode is helpful to improve work efficiency, reduce the finan-cial burden on families, and meet the demand of caregivers, health education and the right to know and sublimation of medical humanism philosophy, promoting the comprehensive qualities of nurses, improve patient satisfaction, harmonious relationship between hospital and patients, improve high quality nursing care for patients.
ABSTRACT
We have found and synthesized a trapping ligand peptide H22-LP (the conservative sequence is NAHCALL) from a random phage library according to the broad-spectrum trapping receptor H22, which derived from the residue 14-35 near the N-terminal region of receptor US28 on HCMV. In this study, we will evaluate its potential as an efficient antagonist of US28 and the anti-virus activity, acting as a broad spectrum chemokine receptors antagonist. Stable expression of US28 and ORF74 in NIH/3T3 cells were successfully constructed in vitro. Flow cytomety was used to determine the concentration of Ca2+ induced by H22-LP, and the binding of H22-LP and US28 was confirmed by enzyme-linked immunosorbent assay (ELISA). Antivirus activity of H22-LP on HCMV and KSHV was evaluated by anti-virus experiments. Our data suggest that H22-LP is an effectual antagonist of receptor US28 of HCMV and ORF74 of KSHV in the transfection assay, and it has potential to inhibit infection of HCMV and KSHV. These results provide support for the development of anti-virus strategies based on targeted inhibiting the infection of herpesvirus.